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The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization.
The disease is traditionally divided into two stages: In general, subsequent readministration of EP doublets is contraindicated in resistant and refractory disease due to the likelihood of undue toxicities myelosuppression and nephrotoxicity, for example without benefit, since therapeutic resistance in these contexts is, with exceptions, construed as a stable and immutable trait [ 11 ].
No guidelines are available about platinum doublet rechallenge after initial and secondary failures. Pretreatment or priming with epigenetic inhibitors, like the approved DNA demethylators, e.
RRx, in particular, has demonstrated evidence of episensitization to refractory irinotecan in the context of a Phase II clinical trial entitled ROCKET in metastatic colorectal cancer [ 161718 ].
Case Report Patient —, a year-old male veteran, former smoker, with a diagnosis of extensive-stage SCLC, completed six cycles of carboplatin and etoposide in December Approximately 1 year after completion of the NIH trial, with symptoms of fatigue and inappetence due to disease progression as well as dyspnea and decreased exercise tolerance from a large unilateral pleural effusion, he enrolled as the first patient — on the TRIPLE THREAT clinical trial at Walter Reed in June After the first dose of RRx, and continuing for the next 8—9 weeks, the patient reported a significantly increased appetite for and consumption of fried foods, specifically pork chops, and desserts, which led to dyspeptic symptoms.
His fatigue, shortness of breath and exercise tolerance also significantly improved to the point that he resumed uphill running and lifting weights.
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Case Report Patient –, a year-old male veteran, former smoker, with a diagnosis of extensive-stage SCLC, completed six cycles of carboplatin and etoposide in December PLATINUM BOX CASE STUDY Statement of Issues The main problem in this Platinum case is the decision whether or not to single source to Jabaking with the expansion of printing equipment.
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